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Record 48 of 6045
Differential effects of catecholamines on in vitro growth of pathogenic bacteria
External Online Source: doi:10.1016/S0024-3205(02)01683-1
Author and Affiliation:
Belay, Tesfaye(Morehouse School of Medicine, Department of Microbiology, Biochemistry, and Immunology, 720 Westview Drive, S.W., Atlanta, GA 30310, United States)
Sonnenfeld, Gerald
Abstract: Supplementation of minimal medium inoculated with bacterial cultures with norepinephrine, epinephrine, dopamine, or isoproterenol resulted in marked increases in growth compared to controls. Norepinephrine and dopamine had the greatest enhancing effects on growth of cultures of Pseudomonas aeruginosa and Klebsiella pneumoniae, while epinephrine and isoproterenol also enhanced growth to a lesser extent. The growth of Escherichia coli in the presence of norepinephrine was greater than growth in the presence of the three other neurochemicals used in the study. Growth of Staphylococcus aureus was also enhanced in the presence of norepinephrine, but not to the same degree as was the growth of gram negative bacteria. Addition of culture supernatants from E. coli cultures that had been grown in the presence of norepinephrine was able to enhance the growth of K. pneumoniae. Addition of the culture supernatant fluid culture from E. coli cultures that had been grown in the presence of norepinephrine did not enhance growth of P. aeruginosa or S. aureus. Culture supernatant fluids from bacteria other than E. coli grown in the presence of norepinephrine were not able to enhance the growth of any bacteria tested. The results suggest that catecholamines can enhance growth of pathogenic bacteria, which may contribute to development of pathogenesis; however, there is no uniform effect of catecholamines on bacterial growth.
Publication Date: Jun 14, 2002
Document ID:
20040088282
(Acquired Sep 07, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Life sciences (ISSN 0024-3205); Volume 71; 4; 447-56
Publisher Information: United Kingdom
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ANTIINFECTIVES AND ANTIBACTERIALS; BACTERIA; CATECHOLAMINE; ESCHERICHIA; IN VITRO METHODS AND TESTS; PATHOGENS; PSEUDOMONAS; STAPHYLOCOCCUS; ANALYSIS OF VARIANCE; CELL DIVISION; KLEBSIELLA
Other Descriptors: ANTI-BACTERIAL AGENTS/PHARMACOLOGY; CATECHOLAMINES/PHARMACOLOGY; ESCHERICHIA COLI/DRUG EFFECTS; PSEUDOMONAS AERUGINOSA/DRUG EFFECTS; STAPHYLOCOCCUS AUREUS/DRUG EFFECTS; ANALYSIS OF VARIANCE; CELL DIVISION/DRUG EFFECTS; KLEBSIELLA PNEUMONIAE/DRUG EFFECTS; MICROBIAL SENSITIVITY TESTS; SUPPORT, U.S. GOV'T, NON-P.H.S; NASA DISCIPLINE REGULATORY PHYSIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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