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Tracks to therapyStudies of the structure of particle tracks have led to models of track effects based on radial dose and radiobiological target theory that have been very successful in describing and predicting track effects in physical, chemical, and biological systems. For describing mammalian cellular inactivation two inactivation modes are required, called gamma-kill and ion-kill, the first due to synergistic effects of delta rays from adjacent ion paths thus resembling the effects from gamma rays, and the second to the effects of single ion transits through a cell nucleus. The ion-kill effect is more severe, where the fraction of cells experiencing ion kill is responsible for a decrease in the oxygen enhancement ratio, and an increase in relative biological effectiveness, but these are accompanied by loss of repair, hence to a reduction in the efficiency of fractionation in high LET therapy, as shown by our calculations for radiobiological effects in the "spread out Bragg Peak".
Document ID
20040088308
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Katz, R.
(University of Nebraska Lincoln, Nebraska 68588-0111, United States)
Cucinotta, F. A.
Date Acquired
August 21, 2013
Publication Date
June 1, 1999
Publication Information
Publication: Radiation measurements
Volume: 31
Issue: 1-6
ISSN: 1350-4487
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
Review
NASA Center JSC
NASA Discipline Radiation Health

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