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Tensile stress stimulates microtubule outgrowth in living cellsCell motility is driven by the sum of asymmetric traction forces exerted on the substrate through adhesion foci that interface with the actin cytoskeleton. Establishment of this asymmetry involves microtubules, which exert a destabilising effect on adhesion foci via targeting events. Here, we demonstrate the existence of a mechano-sensing mechanism that signals microtubule polymerisation and guidance of the microtubules towards adhesion sites under increased stress. Stress was applied either by manipulating the body of cells moving on glass with a microneedle or by stretching a flexible substrate that cells were migrating on. We propose a model for this mechano-sensing phenomenon whereby microtubule polymerisation is stimulated and guided through the interaction of a microtubule tip complex with actin filaments under tension.
Document ID
20040088327
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kaverina, Irina
(Institute of Molecular Biology of the Austrian Academy of Sciences, 5020 Austria)
Krylyshkina, Olga
Beningo, Karen
Anderson, Kurt
Wang, Yu-Li
Small, J. Victor
Date Acquired
August 21, 2013
Publication Date
June 1, 2002
Publication Information
Publication: Journal of cell science
Volume: 115
Issue: Pt 11
ISSN: 0021-9533
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cell Biology
Non-NASA Center

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