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Plasma 24,25-dihydroxyvitamin D concentration of Dahl salt-sensitive rats decreases during high salt intakeDahl salt-sensitive rats, but not salt-resistant rats, develop hypertension in response to high salt intake. We have previously shown an inverse relationship between plasma 25-hydroxyvitamin D (25-OHD) concentration and blood pressure of Dahl salt-sensitive rats during high salt intake. In this study, we report on the relationship between high salt intake and plasma 24,25-dihydroxyvitamin D (24,25-(OH)(2)D) concentration of Dahl salt-sensitive and salt-resistant rats. Rats were fed a high salt diet (8%) and sacrificed at day 2, 7, 14, 21, and 28. Plasma 24,25-(OH)(2)D concentrations of salt-sensitive rats were reduced to 50% of that at baseline at day 2-when blood pressure and plasma 25-OHD concentration were unchanged, but 25-OHD content in the kidney was 81% of that at baseline. Plasma 24,25-(OH)(2)D concentration was reduced further to 10% of that at baseline from day 7 to 14 of high salt intake, a reduction that was prevented in rats switched to a low salt (0.3%) diet at day 7. Exogenous 24,25-dihydroxycholecalciferol (24,25-(OH)(2)D(3)), administered at a level that increased plasma 24,25-(OH)(2)D concentration to five times normal, did not attenuate the salt-induced hypertension of salt-sensitive rats. Plasma 24,25-(OH)(2)D concentration of salt-resistant rats was gradually reduced to 50% of that at baseline at day 14 and returned to baseline value at day 28 of high salt intake. We conclude that the decrease in plasma 24,25-(OH)(2)D concentration in salt-sensitive rats during high salt intake is caused by decreased 25-OHD content in the kidney and also by another unidentified mechanism.
Document ID
20040088385
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Thierry-Palmer, Myrtle
(Morehouse School of Medicine 720 Westview Drive, SW, Atlanta, GA 30310-1495, United States)
Tewolde, Teclemicael K.
Forte, Camille
Wang, Min
Bayorh, Mohamed A.
Emmett, Nerimiah L.
White, Jolanda
Griffin, Keri
Date Acquired
August 21, 2013
Publication Date
March 1, 2002
Publication Information
Publication: The Journal of steroid biochemistry and molecular biology
Volume: 80
Issue: 3
ISSN: 0960-0760
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: RR03034
CONTRACT_GRANT: S06 GM08248
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Cardiopulmonary

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