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A genomic regulatory network for developmentDevelopment of the body plan is controlled by large networks of regulatory genes. A gene regulatory network that controls the specification of endoderm and mesoderm in the sea urchin embryo is summarized here. The network was derived from large-scale perturbation analyses, in combination with computational methodologies, genomic data, cis-regulatory analysis, and molecular embryology. The network contains over 40 genes at present, and each node can be directly verified at the DNA sequence level by cis-regulatory analysis. Its architecture reveals specific and general aspects of development, such as how given cells generate their ordained fates in the embryo and why the process moves inexorably forward in developmental time.
Document ID
20040088430
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Davidson, Eric H.
(California Institute of Technology Pasadena, CA 91125, United States)
Rast, Jonathan P.
Oliveri, Paola
Ransick, Andrew
Calestani, Cristina
Yuh, Chiou-Hwa
Minokawa, Takuya
Amore, Gabriele
Hinman, Veronica
Arenas-Mena, Cesar
Otim, Ochan
Brown, C. Titus
Livi, Carolina B.
Lee, Pei Yun
Revilla, Roger
Rust, Alistair G.
Pan, Zheng jun
Schilstra, Maria J.
Clarke, Peter J C.
Arnone, Maria I.
Rowen, Lee
Cameron, R. Andrew
McClay, David R.
Hood, Leroy
Bolouri, Hamid
Date Acquired
August 21, 2013
Publication Date
March 1, 2002
Publication Information
Publication: Science
Volume: 295
Issue: 5560
ISSN: 0036-8075
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: RR-15044
CONTRACT_GRANT: RR-06591
CONTRACT_GRANT: HD-37105
CONTRACT_GRANT: GM-61005
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Evolutionary Biology
Review
Review, Tutorial

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