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The calcium endocrine system of adolescent rhesus monkeys and controls before and after spaceflightThe calcium endocrine system of nonhuman primates can be influenced by chairing for safety and the weightless environment of spaceflight. The serum of two rhesus monkeys flown on the Bion 11 mission was assayed pre- and postflight for vitamin D metabolites, parathyroid hormone, calcitonin, parameters of calcium homeostasis, cortisol, and indexes of renal function. Results were compared with the same measures from five monkeys before and after chairing for a flight simulation study. Concentrations of 1,25-dihydroxyvitamin D were 72% lower after the flight than before, and more than after chairing on the ground (57%, P < 0.05). Decreases in parathyroid hormone did not reach significance. Calcitonin showed modest decreases postflight (P < 0.02). Overall, effects of spaceflight on the calcium endocrine system were similar to the effects of chairing on the ground, but were more pronounced. Reduced intestinal calcium absorption, losses in body weight, increases in cortisol, and higher postflight blood urea nitrogen were the changes in flight monkeys that distinguished them from the flight simulation study animals.
Document ID
20040088483
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Arnaud, Sara B.
(NASA Ames Research Center Moffett Field CA United States)
Navidi, Meena
Deftos, Leonard
Thierry-Palmer, Myrtle
Dotsenko, Rita
Bigbee, Allison
Grindeland, Richard E.
Date Acquired
August 21, 2013
Publication Date
March 1, 2002
Publication Information
Publication: American journal of physiology. Endocrinology and metabolism
Volume: 282
Issue: 3
ISSN: 0193-1849
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Center ARC
Flight Experiment
Bion 11 Project
NASA Discipline Regulatory Physiology
Non-NASA Center
short duration
unmanned

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