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Water deprivation-induced sodium appetite: humoral and cardiovascular mediators and immediate early genesAdult rats deprived of water for 24-30 h were allowed to rehydrate by ingesting only water for 1-2 h. Rats were then given access to both water and 1.8% NaCl. This procedure induced a sodium appetite defined by the operational criteria of a significant increase in 1.8% NaCl intake (3.8 +/- 0.8 ml/2 h; n = 6). Expression of Fos (as assessed by immunohistochemistry) was increased in the organum vasculosum of the lamina terminalis (OVLT), median preoptic nucleus (MnPO), subfornical organ (SFO), and supraoptic nucleus (SON) after water deprivation. After rehydration with water but before consumption of 1.8% NaCl, Fos expression in the SON disappeared and was partially reduced in the OVLT and MnPO. However, Fos expression did not change in the SFO. Water deprivation also 1) increased plasma renin activity (PRA), osmolality, and plasma Na+; 2) decreased blood volume; and 3) reduced total body Na+; but 4) did not alter arterial blood pressure. Rehydration with water alone caused only plasma osmolality and plasma Na+ concentration to revert to euhydrated levels. The changes in Fos expression and PRA are consistent with a proposed role for ANG II in the control of the sodium appetite produced by water deprivation followed by rehydration with only water.
Document ID
20040088521
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
De Luca, Laurival A Jr
(School of Dentistry, Paulista State University Sao Paulo 14801-903, Araraquara, Brazil)
Xu, Zhice
Schoorlemmer, Guus H M.
Thunhorst, Robert L.
Beltz, Terry G.
Menani, Jose V.
Johnson, Alan Kim
Date Acquired
August 21, 2013
Publication Date
February 1, 2002
Publication Information
Publication: American journal of physiology. Regulatory, integrative and comparative physiology
Volume: 282
Issue: 2
ISSN: 0363-6119
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: HL-57472
CONTRACT_GRANT: HL-14338
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology

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