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Record 1 of 1020
Blood pressure and mesenteric resistance arterial function after spaceflight
Author and Affiliation:
Hatton, Daniel C.(Oregon Health Sciences University, Department of Nephrology, Hypertension, and Clinical Pharmacology, Portland, Oregon 97201, United States)
Yue, Qi
Chapman, Justin
Xue, Hong
Dierickx, Jacqueline
Roullet, Chantal
Coste, Sarah
Roullet, Jean Baptiste
McCarron, David A.
Abstract: Ground studies indicate that spaceflight may diminish vascular contraction. To examine that possibility, vascular function was measured in spontaneously hypertensive rats immediately after an 18-day shuttle flight. Isolated mesenteric resistance arterial responses to cumulative additions of norepinephrine, acetylcholine, and sodium nitroprusside were measured using wire myography within 17 h of landing. After flight, maximal contraction to norepinephrine was attenuated (P < 0.001) as was relaxation to acetylcholine (P < 0.001) and sodium nitroprusside (P < 0.05). At high concentrations, acetylcholine caused vascular contraction in vessels from flight animals but not in vessels from vivarium control animals (P < 0.05). The results are consistent with data from ground studies and indicate that spaceflight causes both endothelial-dependent and endothelial-independent alterations in vascular function. The resulting decrement in vascular function may contribute to orthostatic intolerance after spaceflight.
Publication Date: Jan 01, 2002
Document ID:
20040088605
(Acquired Sep 07, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Journal of applied physiology (Bethesda, Md. : 1985) (ISSN 8750-7587); Volume 92; 1; 13-7
Publisher Information: United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ARTERIES; BLOOD CIRCULATION; BLOOD FLOW; BLOOD PRESSURE; HEMODYNAMICS; SPACE FLIGHT; ACETYLCHOLINE; CYANIDES; MALES; MUSCULAR FUNCTION; NITROGEN COMPOUNDS; RATS; SMOOTH MUSCLE; SPACE SHUTTLE MISSIONS; VASODILATOR AGENTS
Other Descriptors: BLOOD PRESSURE/PHYSIOLOGY; MESENTERIC ARTERIES/ANATOMY & HISTOLOGY/PHYSIOLOGY; SPACE FLIGHT; SPLANCHNIC CIRCULATION/PHYSIOLOGY; VASCULAR RESISTANCE/PHYSIOLOGY; ACETYLCHOLINE/PHARMACOLOGY; ANIMALS; MALE; MUSCLE RELAXATION/DRUG EFFECTS; MUSCLE, SMOOTH, VASCULAR/DRUG EFFECTS; NITROPRUSSIDE/PHARMACOLOGY; RATS; RATS, INBRED SHR; SUPPORT, U.S. GOV'T, NON-P.H.S; VASODILATOR AGENTS/PHARMACOLOGY; FLIGHT EXPERIMENT; STS-80 SHUTTLE PROJECT; MANNED; SHORT DURATION; NASA DISCIPLINE CARDIOPULMONARY; NASA EXPERIMENT NUMBER 9401686; NON-NASA CENTER
Availability Source: Other Sources
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