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Biology of bone and how it orchestrates the form and function of the skeletonThe principal role of the skeleton is to provide structural support for the body. While the skeleton also serves as the body's mineral reservoir, the mineralized structure is the very basis of posture, opposes muscular contraction resulting in motion, withstands functional load bearing, and protects internal organs. Although the mass and morphology of the skeleton is defined, to some extent, by genetic determinants, it is the tissue's ability to remodel--the local resorption and formation of bone--which is responsible for achieving this intricate balance between competing responsibilities. The aim of this review is to address bone's form-function relationship, beginning with extensive research in the musculoskeletal disciplines, and focusing on several recent cellular and molecular discoveries which help understand the complex interdependence of bone cells, growth factors, physical stimuli, metabolic demands, and structural responsibilities. With a clinical and spine-oriented audience in mind, the principles of bone cell and molecular biology and physiology are presented, and an attempt has been made to incorporate epidemiologic data and therapeutic implications. Bone research remains interdisciplinary by nature, and a deeper understanding of bone biology will ultimately lead to advances in the treatment of diseases and injuries to bone itself.
Document ID
20040088636
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Sommerfeldt, D. W.
(State University of New York Stony Brook, United States)
Rubin, C. T.
Date Acquired
August 21, 2013
Publication Date
October 1, 2001
Publication Information
Publication: European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society
Volume: 10 Suppl 2
ISSN: 0940-6719
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AR39278
CONTRACT_GRANT: AR43498
CONTRACT_GRANT: AR41040
CONTRACT_GRANT: AR41011
Distribution Limits
Public
Copyright
Other
Keywords
Review
Non-NASA Center
Review, Tutorial
NASA Discipline Musculoskeletal

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