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Record Details

Record 9 of 6261
Time course of the MAPK and PI3-kinase response within 24 h of skeletal muscle overload
Author and Affiliation:
Carlson, C. J.(University of Texas Health Science Center at Houston, Graduate School of Biomedical Sciences, Houston, Texas 77030, United States)
Fan, Z.
Gordon, S. E.
Booth, F. W.
Abstract: Knowledge of the molecular mechanisms by which skeletal muscle hypertrophies in response to increased mechanical loading may lead to the discovery of novel treatment strategies for muscle wasting and frailty. To gain insight into potential early signaling mechanisms associated with skeletal muscle hypertrophy, the temporal pattern of mitogen-activated protein kinase (MAPK) phosphorylation and phosphatidylinositol 3-kinase (PI3-kinase) activity during the first 24 h of muscle overload was determined in the rat slow-twitch soleus and fast-twitch plantaris muscles after ablation of the gastrocnemius muscle. p38alpha MAPK phosphorylation was elevated for the entire 24-h overload period in both muscles. In contrast, Erk 2 and p54 JNK phosphorylation were transiently increased by overload, returning to the levels of sham-operated controls by 24 h. PI3-kinase activity was increased by muscle overload only at 12 h of overload and only in the plantaris muscle. In summary, sustained elevation of p38alpha MAPK phosphorylation occurred early in response to muscle overload, identifying this pathway as a potential candidate for mediating early hypertrophic signals in response to skeletal muscle overload.
Publication Date: Nov 01, 2001
Document ID:
20040088710
(Acquired Sep 07, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: Journal of applied physiology (Bethesda, Md. : 1985) (ISSN 8750-7587); Volume 91; 5; 2079-87
Publisher Information: United States
Contract/Grant/Task Num: AR-19393
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: MUSCLES; MUSCULOSKELETAL SYSTEM; PHYSICAL WORK; SKELETAL MUSCLE; DENSITY MEASUREMENT; KINETICS; MALES; ORGAN WEIGHT; PROTEINS; RATS; SIGNAL TRANSMISSION
Other Descriptors: 1-PHOSPHATIDYLINOSITOL 3-KINASE/BIOSYNTHESIS; EXERTION/PHYSIOLOGY; MITOGEN-ACTIVATED PROTEIN KINASES/BIOSYNTHESIS; MUSCLE, SKELETAL/ENZYMOLOGY; ANIMALS; DENSITOMETRY; KINETICS; MALE; MUSCLE PROTEINS/METABOLISM; ORGAN WEIGHT/PHYSIOLOGY; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION/PHYSIOLOGY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; P42 MAP KINASE/BIOSYNTHESIS; NASA DISCIPLINE MUSCULOSKELETAL; NON-NASA CENTER
Availability Source: Other Sources
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