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Crosstalk between p38, Hsp25 and Akt in spinal motor neurons after sciatic nerve injuryThe p38 stress-activated protein kinase pathway is involved in regulation of phosphorylation of Hsp25, which in turn regulates actin filament dynamic in non-neuronal cells. We report that p38, Hsp25 and Akt signaling pathways were specifically activated in spinal motor neurons after sciatic nerve axotomy. The activation of the p38 kinase was required for induction of Hsp25 expression. Furthermore, Hsp25 formed a complex with Akt, a member of PI-3 kinase pathway that prevents neuronal cell death. Together, our observations implicate Hsp25 as a central player in a complex system of signaling that may both promote regeneration of nerve fibers and prevent neuronal cell death in the injured spinal cord.
Document ID
Document Type
Reprint (Version printed in journal)
Murashov, A. K. (The Brody School of Medicine at East Carolina University Greenville, NC 27858, United States)
Ul Haq, I.
Hill, C.
Park, E.
Smith, M.
Wang, X.
Wang, X.
Goldberg, D. J.
Wolgemuth, D. J.
Date Acquired
August 21, 2013
Publication Date
September 30, 2001
Publication Information
Publication: Brain research. Molecular brain research
Volume: 93
Issue: 2
ISSN: 0169-328X
Subject Category
Life Sciences (General)
Distribution Limits
NASA Discipline Developmental Biology
Non-NASA Center