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A comparison of RNA with DNA in template-directed synthesisNonenzymatic template-directed copying of RNA sequences rich in cytidylic acid using nucleoside 5'-(2-methylimidazol-1-yl phosphates) as substrates is substantially more efficient than the copying of corresponding DNA sequences. However, many sequences cannot be copied, and the prospect of replication in this system is remote, even for RNA. Surprisingly, wobble-pairing leads to much more efficient incorporation of G opposite U on RNA templates than of G opposite T on DNA templates.
Document ID
20040088802
Acquisition Source
Goddard Space Flight Center
Document Type
Reprint (Version printed in journal)
Authors
Zielinski, M.
(The Salk Institute for Biological Studies San Diego, CA 92186, United States)
Kozlov, I. A.
Orgel, L. E.
Bada, J. L.
Date Acquired
August 21, 2013
Publication Date
September 1, 2000
Publication Information
Publication: Helvetica chimica acta
Volume: 83
Issue: 8
ISSN: 0018-019X
Subject Category
Exobiology
Funding Number(s)
CONTRACT_GRANT: NAG5-4546
CONTRACT_GRANT: NAG5-8512
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Exobiology

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