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Effect of spaceflight on the isotonic contractile properties of single skeletal muscle fibers in the rhesus monkeyExperiments from both Cosmos and Space Shuttle missions have shown weightlessness to result in a rapid decline in the mass and force of rat hindlimb extensor muscles. Additionally, despite an increased maximal shortening velocity, peak power was reduced in rat soleus muscle post-flight. In humans, declines in voluntary peak isometric ankle extensor torque ranging from 15-40% have been reported following long- and short-term spaceflight and prolonged bed rest. Complete understanding of the cellular events responsible for the fiber atrophy and the decline in force, as well as the development of effective countermeasures, will require detailed knowledge of how the physiological and biochemical processes of muscle function are altered by spaceflight. The specific purpose of this investigation was to determine the extent to which the isotonic contractile properties of the slow- and fast-twitch fiber types of the soleus and gastrocnemius muscles of rhesus monkeys (Macaca mulatta) were altered by a 14-day spaceflight.
Document ID
20040088842
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Fitts, R. H.
(Marquette University Milwaukee, WI, United States)
Romatowski, J. G.
Blaser, C.
De La Cruz, L.
Gettelman, G. J.
Widrick, J. J.
Date Acquired
August 21, 2013
Publication Date
January 1, 2000
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 7
Issue: 1
ISSN: 1077-9248
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
short duration
Bion 11 Project
Flight Experiment
unmanned
NASA Experiment Number 8913020 2/2
NASA Discipline Musculoskeletal

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