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Fiber size and myosin phenotypes of selected rhesus lower limb muscles after a 14-day spaceflightMuscle biopsies were taken from the rhesus (Macaca mulatta) soleus (Sol, a slow ankle extensor), medial gastrocnemius (MG, a fast ankle extensor), tibialis anterior (TA, a fast ankle flexor), and vastus lateralis (VL, a fast knee extensor) muscles in vivarium controls (n=5) before and after either a 14-day spaceflight (Bion 11, n=2) or a 14-day ground-based flight simulation (n=3). Myosin heavy chain (MHC) composition (gel electrophoresis), fiber type distribution (immunohistochemistry), and fiber size were determined. Although there were no significant changes, each muscle showed trends towards adaptation.
Document ID
20040088843
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Roy, R. R.
(Brain Research Institute, University of California Los Angeles, United States)
Zhong, H.
Bodine, S. C.
Pierotti, D. J.
Talmadge, R. J.
Barkhoudarian, G.
Kim, J.
Fanton, J. W.
Kozlovskaya, I. B.
Edgerton, V. R.
Date Acquired
August 21, 2013
Publication Date
January 1, 2000
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 7
Issue: 1
ISSN: 1077-9248
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Flight Experiment
short duration
Non-NASA Center
Bion 11 Project
NASA Experiment Number B11-03A
unmanned

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