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Reduced receptor aggregation and altered cytoskeleton in cultured myocytes after space-flightWe carried out parallel experiments first on the slow clinostat and then in space-flight to examine the effects of altered gravity on the aggregation of the nicotinic acetylcholine receptors and the structure of the cytoskeleton in cultured Xenopus embryonic muscle cells. By examining the concordance between results from space flight and the clinostat, we tested whether the slow clinostat is a relevant simulation paradigm. Space-flown cells showed marked changes in the distribution and organization of actin filaments and had a reduced incidence of acetylcholine receptor aggregates at the site of contact with polystyrene beads. Similar effects were found after clinostat rotation. The sensitivity of synaptic receptor aggregation and cytoskeletal morphology suggests that in the microgravity of space cell behavior may be importantly altered.
Document ID
20040088952
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gruener, R.
(University of Arizona Tucson 85724, United States)
Roberts, R.
Reitstetter, R.
Date Acquired
August 21, 2013
Publication Date
June 1, 1994
Publication Information
Publication: Uchu seibutsu kagaku
Volume: 8
Issue: 2
ISSN: 0914-9201
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: PRSkP0-810
CONTRACT_GRANT: HL-07249
Distribution Limits
Public
Copyright
Other
Keywords
STS-56 Shuttle Project
Flight Experiment
STS-52 Shuttle Project
manned
NASA Discipline Cell Biology
Non-NASA Center
short duration

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