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Record Details

Record 15 of 733
Reduced receptor aggregation and altered cytoskeleton in cultured myocytes after space-flight
Author and Affiliation:
Gruener, R.(University of Arizona, Department of Physiology, Tucson 85724, United States)
Roberts, R.
Reitstetter, R.
Abstract: We carried out parallel experiments first on the slow clinostat and then in space-flight to examine the effects of altered gravity on the aggregation of the nicotinic acetylcholine receptors and the structure of the cytoskeleton in cultured Xenopus embryonic muscle cells. By examining the concordance between results from space flight and the clinostat, we tested whether the slow clinostat is a relevant simulation paradigm. Space-flown cells showed marked changes in the distribution and organization of actin filaments and had a reduced incidence of acetylcholine receptor aggregates at the site of contact with polystyrene beads. Similar effects were found after clinostat rotation. The sensitivity of synaptic receptor aggregation and cytoskeletal morphology suggests that in the microgravity of space cell behavior may be importantly altered.
Publication Date: Jun 01, 1994
Document ID:
20040088952
(Acquired Sep 07, 2004)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Uchu seibutsu kagaku (ISSN 0914-9201); Volume 8; 2; 79-93
Publisher Information: Japan
Contract/Grant/Task Num: PRSkP0-810; HL-07249
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: MUSCLE FIBERS; PROTEINS; ROTATION; SKELETAL MUSCLE; WEIGHTLESSNESS; ACETYLCHOLINE; AEROSPACE MEDICINE; AMPHIBIA; CULTURED CELLS; CYTOLOGY; CYTOPLASM; EMBRYOS; GRAVITATION; GRAVITATIONAL PHYSIOLOGY; NEURONS; SPACE SHUTTLE MISSIONS; SYNAPSES; WEIGHTLESSNESS SIMULATION
Other Descriptors: ACTINS/PHYSIOLOGY/ULTRASTRUCTURE; MUSCLE, SKELETAL/CYTOLOGY/PHYSIOLOGY/ULTRASTRUCTURE; RECEPTOR AGGREGATION; RECEPTORS, CHOLINERGIC/PHYSIOLOGY; ROTATION; SPACE FLIGHT; WEIGHTLESSNESS; ACETYLCHOLINE; ANIMALS; CELL PHYSIOLOGY; CELLS, CULTURED; COMPARATIVE STUDY; CYTOSKELETON/PHYSIOLOGY/ULTRASTRUCTURE; EMBRYO, NONMAMMALIAN; GRAVITATION; MICROSPHERES; NEUROMUSCULAR JUNCTION/PHYSIOLOGY; NEURONS/PHYSIOLOGY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; WEIGHTLESSNESS SIMULATION; XENOPUS LAEVIS/EMBRYOLOGY; FLIGHT EXPERIMENT; STS-52 SHUTTLE PROJECT; STS-56 SHUTTLE PROJECT; MANNED; SHORT DURATION; NASA DISCIPLINE CELL BIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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