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Record 3 of 437
Vector-averaged gravity does not alter acetylcholine receptor single channel properties
Author and Affiliation:
Reitstetter, R.(University of Arizona, Department of Physiology, Tucson 85724, United States)
Gruener, R.
Abstract: To examine the physiological sensitivity of membrane receptors to altered gravity, we examined the single channel properties of the acetylcholine receptor (AChR), in co-cultures of Xenopus myocytes and neurons, to vector-averaged gravity in the clinostat. This experimental paradigm produces an environment in which, from the cell's perspective, the gravitational vector is "nulled" by continuous averaging. In that respect, the clinostat simulates one aspect of space microgravity where the gravity force is greatly reduced. After clinorotation, the AChR channel mean open-time and conductance were statistically not different from control values but showed a rotation-dependent trend that suggests a process of cellular adaptation to clinorotation. These findings therefore suggest that the ACHR channel function may not be affected in the microgravity of space despite changes in the receptor's cellular organization.
Publication Date: Jun 01, 1994
Document ID:
20040088953
(Acquired Sep 07, 2004)
Subject Category: AEROSPACE MEDICINE
Document Type: Journal Article
Publication Information: Uchu seibutsu kagaku; p. 71-8; (ISSN 0914-9201); Volume 8; 2
Publisher Information: Japan
Contract/Grant/Task Num: HL 07249; NAGW-1705
Financial Sponsor: NASA; Washington DC United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: ACETYL COMPOUNDS; CHOLINE; GRAVITATION; ION CHANNELS (BIOLOGY); ROTATION; SKELETAL MUSCLE; ACETYLCHOLINE; AEROSPACE MEDICINE; AMPHIBIA; CULTURED CELLS; CYTOLOGY; EMBRYOLOGY; EMBRYOS; GRAVITATIONAL PHYSIOLOGY; NEURONS; WEIGHTLESSNESS SIMULATION
Other Descriptors: ION CHANNELS/PHYSIOLOGY; MUSCLE, SKELETAL/CYTOLOGY/EMBRYOLOGY/PHYSIOLOGY; RECEPTORS, CHOLINERGIC/PHYSIOLOGY; ROTATION; ACETYLCHOLINE; ANIMALS; CELLS, CULTURED; EMBRYO, NONMAMMALIAN; GRAVITATION; GRAVITY, ALTERED; NEURONS/PHYSIOLOGY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S; SUPPORT, U.S. GOV'T, P.H.S; WEIGHTLESSNESS SIMULATION; XENOPUS LAEVIS/EMBRYOLOGY; NASA DISCIPLINE CELL BIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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