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Multistep modeling of protein structure: application towards refinement of tyr-tRNA synthetaseThe scope of multistep modeling (MSM) is expanding by adding a least-squares minimization step in the procedure to fit backbone reconstruction consistent with a set of C-alpha coordinates. The analytical solution of Phi and Psi angles, that fits a C-alpha x-ray coordinate is used for tyr-tRNA synthetase. Phi and Psi angles for the region where the above mentioned method fails, are obtained by minimizing the difference in C-alpha distances between the computed model and the crystal structure in a least-squares sense. We present a stepwise application of this part of MSM to the determination of the complete backbone geometry of the 321 N terminal residues of tyrosine tRNA synthetase to a root mean square deviation of 0.47 angstroms from the crystallographic C-alpha coordinates.
Document ID
20040089091
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Srinivasan, S.
(Roswell Park Memorial Institute Buffalo, New York 14263, United States)
Shibata, M.
Roychoudhury, M.
Rein, R.
Date Acquired
August 21, 2013
Publication Date
January 1, 1987
Publication Information
Publication: International journal of quantum chemistry. Quantum biology symposium : proceedings of the International Symposium on Quantum Biology and Quantum Pharmacology. International Symposium on Quantum Biology and Quantum Pharmacology
Volume: 14
ISSN: 0360-8832
Subject Category
Exobiology
Funding Number(s)
CONTRACT_GRANT: NSG-7305
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Exobiology
Non-NASA Center

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