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Multistep modeling (MSM) of biomolecular structure application to the A-G mispair in the B-DNA environmentA multistep modeling procedure has been evolved to study the structural changes introduced by lesions in DNA. We report here the change in the structure of regular B-DNA geometry due to the incorporation of Ganti-Aanti mispair in place of a regular G-C pair, preserving the helix continuity. The energetics of the structure so obtained is compared with the Ganti-Asyn configuration under similar constrained conditions. We present the methodology adopted and discuss the results.
Document ID
20040089116
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Srinivasan, S.
(Roswell Park Memorial Institute Buffalo, NY 14263, United States)
Raghunathan, G.
Shibata, M.
Rein, R.
Date Acquired
August 21, 2013
Publication Date
January 1, 1986
Publication Information
Publication: International journal of quantum chemistry. Quantum biology symposium : proceedings of the International Symposium on Quantum Biology and Quantum Pharmacology. International Symposium on Quantum Biology and Quantum Pharmacology
Volume: 12
ISSN: 0360-8832
Subject Category
Exobiology
Funding Number(s)
CONTRACT_GRANT: NSG-7305
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Exobiology

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