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Microgravity cultivation of cells and tissuesIn vitro studies of cells and tissues in microgravity, either simulated by cultivation conditions on earth or actual, during spaceflight, are expected to help identify mechanisms underlying gravity sensing and transduction in biological organisms. In this paper, we review rotating bioreactor studies of engineered skeletal and cardiovascular tissues carried out in unit gravity, a four month long cartilage tissue engineering study carried out aboard the Mir Space Station, and the ongoing laboratory development and testing of a system for cell and tissue cultivation aboard the International Space Station.
Document ID
20040089167
Document Type
Reprint (Version printed in journal)
Authors
Freed, L. E. (Massachusetts Institute of Technology Cambridge, MA, United States)
Pellis, N.
Searby, N.
de Luis, J.
Preda, C.
Bordonaro, J.
Vunjak-Novakovic, G.
Date Acquired
August 21, 2013
Publication Date
May 1, 1999
Publication Information
Publication: Gravitational and space biology bulletin : publication of the American Society for Gravitational and Space Biology
Volume: 12
Issue: 2
ISSN: 1089-988X
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NAG9-836
CONTRACT_GRANT: CCU9-7001
Distribution Limits
Public
Copyright
Other
Keywords
Review, Tutorial
NASA Center JSC
Flight Experiment
Review
Mir Project
manned
long duration
NASA Discipline Cell Biology