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Bone tissue engineering: the role of interstitial fluid flowIt is well established that vascularization is required for effective bone healing. This implies that blood flow and interstitial fluid (ISF) flow are required for healing and maintenance of bone. The fact that changes in bone blood flow and ISF flow are associated with changes in bone remodeling and formation support this theory. ISF flow in bone results from transcortical pressure gradients produced by vascular and hydrostatic pressure, and mechanical loading. Conditions observed to alter flow rates include increases in venous pressure in hypertension, fluid shifts occurring in bedrest and microgravity, increases in vascularization during the injury-healing response, and mechanical compression and bending of bone during exercise. These conditions also induce changes in bone remodeling. Previously, we hypothesized that interstitial fluid flow in bone, and in particular fluid shear stress, serves to mediate signal transduction in mechanical loading- and injury-induced remodeling. In addition, we proposed that a lack or decrease of ISF flow results in the bone loss observed in disuse and microgravity. The purpose of this article is to review ISF flow in bone and its role in osteogenesis.
Document ID
20040089321
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Hillsley, M. V.
(University Park 16802 United States)
Frangos, J. A.
Date Acquired
August 21, 2013
Publication Date
March 25, 1994
Publication Information
Publication: Biotechnology and bioengineering
Volume: 43
Issue: 7
ISSN: 0006-3592
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NAGW-3358
Distribution Limits
Public
Copyright
Other
Keywords
Review
NASA Discipline Cell Biology
Review, Tutorial
Non-NASA Center

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