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The preservation of urine samples for determination of renal stone risk factorsA preservation technique for urine specimens before determination of stone risk factors was evaluated. The purpose of these experiments was to prove the effectiveness of the preservatives used to prevent changes in the concentrations of those constituents measured. Measured concentrations in fresh specimens were compared with those in the same specimens after storage with the preservatives. Refrigeration at 4 degrees C up to five days was appropriate in a laboratory setting, as no significant changes in urinary concentrations occurred. Refrigeration, however, did not offer a convenient method for shipping. Chemical preservation was found to be an effective alternative to refrigeration. Thymol prevented changes in concentration of pH, citrate, uric acid, sulfate, sodium, potassium, and cyclic AMP, while a mixture of hydrochloric (HCl) acid and boric acid prevented changes in calcium, magnesium, phosphorus, oxalate, ammonium, and creatinine. Thus, the addition of thymol or HCl/boric acid to urine specimens will prevent significant changes in the concentrations of stone risk factors.
Document ID
20040089815
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Nicar, M. J.
(Southwestern Medical School of the University of Texas Health Science Center at Dallas TX 75235, United States)
Hsu, M. C.
Johnson, T.
Pak, C. Y.
Date Acquired
August 21, 2013
Publication Date
June 1, 1987
Publication Information
Publication: Laboratory medicine
Volume: 18
Issue: 6
ISSN: 0007-5027
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Number 21-50
NASA Program Space Medicine
NASA Discipline Regulatory Physiology

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