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Micronucleation in the lens epithelium following in vivo exposure to physical and chemical mutagensRats were exposed to cataractogenic doses of known physical and chemical genotoxic agents in order to study the efficacy of using micronuclei to monitor mutagenicity in the lens epithelium. The total numbers of micronuclei were counted in lens epithelia from rats exposed to graded doses of either 250 kVp X-rays or the anti-leukemic drug, 1,4 dimethanesulfonoxybutane (Myleran (R)). The results indicate a dose-dependent incidence of micronucleation in the lens epithelium following exposure. The findings are consistent with the hypothesis that the cataractogenicity of certain agents may be related to their effect on the genome of lens epithelial cells.
Document ID
20040089876
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Odrich, S.
(College of Physicians & Surgeons of Columbia University, Department of Ophthalmology New York 10032, United States)
Medvedovsky, C.
Merriam, G. R. Jr
Worgul, B. V.
Date Acquired
August 21, 2013
Publication Date
January 1, 1988
Publication Information
Publication: Lens research
Volume: 5
Issue: 4-Mar
ISSN: 0738-1441
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: EY-02648
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Number 22-70
Non-NASA Center
NASA Program Biomedical Research
NASA Discipline Radiation Health

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