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Damage to the photoreceptor cells of the rabbit retina from 56Fe ions: effect of age at exposure, 1Optic and proximate tissues of New Zealand white (NZW) rabbits at ages (approximately 3.5 years) near the middle of their median lifespan (5-7 years) were given 0.5-3.5 Gy of 465 MeV u-1 56Fe ions in the Bragg plateau region of energy deposition at a linear energy transfer (LET infinity) of 220 +/- 31 keV micrometer-1. Dose-dependent losses of retinal photoreceptor cells (rods) occurred until 1-2 years after irradiation, the period of this interim report. Similar cumulative losses of photoreceptor cells were seen during the period 1-2 years post-irradiation for rabbits given comparable exposures when young (6-9 weeks old). Since losses of photoreceptor cells at early times had not been determined previously, the current experiment, which was designed to simulate the responses of mature astronauts, redressed that deficiency.
Document ID
20040089881
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Williams, G. R.
(Colorado State University Fort Collins 80523, United States)
Lett, J. T.
Chatterjee, A.
Date Acquired
August 21, 2013
Publication Date
January 1, 1996
Publication Information
Publication: Advances in space research : the official journal of the Committee on Space Research (COSPAR)
Volume: 18
Issue: 2-Jan
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NAGW-3957
Distribution Limits
Public
Copyright
Other
Keywords
NASA Program NSCORT
NASA Discipline Radiation Health
NASA Discipline Number 93-10
Non-NASA Center

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