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Feeding-associated alterations in striatal neurotransmitter releasePublished evidence suggests a role for dopaminergic (DA) brain pathways in feeding-associated behaviors. Using the novel technique of brain microdialysis of striatal extracellular fluid (ECF) as an index of DA release, Church et al. described increases in levels of DA when animals had limited access to pellets, but not with free access. Dopamine release from the nucleus accumbens did increase with free access to pellets post starvation or after food reward. We used permanently implanted microdialysis probes to measure ECF levels of DA, DOPAC, HVA, and large neutral amino acids (LNAA) for up to 72 hours after implantation among rats experiencing different dietary regimens.
Document ID
Document Type
Reprint (Version printed in journal)
Acworth, I. N.
(Massachusetts Institute of Technology Cambridge 02139, United States)
Ressler, K.
Wurtman, R. J.
Date Acquired
August 21, 2013
Publication Date
December 18, 1989
Publication Information
Publication: Annals of the New York Academy of Sciences
Volume: 575
ISSN: 0077-8923
Subject Category
Life Sciences (General)
Distribution Limits
NASA Discipline Regulatory Physiology
NASA Discipline Number 18-10
Non-NASA Center
NASA Program Biomedical Research

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