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Angiotensin converting enzyme inhibition and the kidneyAngiotensin II (Ang II) induces a marked reduction in renal blood flow at doses well below those required to induce a pressor response, and as blood flow falls there is a decline in glomerular filtration rate and sodium excretion. This striking sensitivity of the renal blood supply led many workers to consider the possibility that angiotensin functions as a local renal hormone. As angiotensin converting enzyme (ACE) was found in particular abundance in the lung, it seemed reasonable to suspect that most of the conversion occurred there, and that the function of Ang II would be primarily systemic, rather than intrarenal. In this review, I will explore the evidence that has accumulated on these two possibilities, since they have important implications for our current understanding of normal kidney function and derangements of kidney function in disease.
Document ID
20040089921
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Hollenberg, N. K.
(Harvard Medical School Boston, MA, United States)
Date Acquired
August 21, 2013
Publication Date
January 1, 1988
Publication Information
Publication: Current opinion in cardiology
Volume: 3
Issue: Suppl 1
ISSN: 0268-4705
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: 5 RO1 HL 36201-02
CONTRACT_GRANT: 1 RO1 HL 36201-02
CONTRACT_GRANT: 7 RO1 HL 36001-03
Distribution Limits
Public
Copyright
Other
Keywords
NASA Program Biomedical Research
NASA Discipline Regulatory Physiology
Review
Review, Tutorial
Non-NASA Center
NASA Discipline Number 21-50

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