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Hypergravity signal transduction and gene expression in cultured mammalian cellsA number of studies have been conducted during space flight and with clinostats and centrifuges, suggesting that gravity effects the proliferation and differentiation of mammalian cells in vitro. However, little is known about the mechanisms by which mammalian cells respond to changes in gravitational stress. This paper summarizes studies designed to clarify the effects of hypergravity on the cultured human HeLa cells and to investigate the mechanism of hypergravity signal transduction in these cells.
Document ID
20040089959
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Kumei, Y.
(NASA Johnson Space Center Houston TX United States)
Whitson, P. A.
Date Acquired
August 21, 2013
Publication Date
May 1, 1994
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 1
Issue: 1
ISSN: 1077-9248
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Center JSC
NASA Program Space Biology
NASA Discipline Cell Biology
NASA Discipline Number 40-20
NASA Discipline Developmental Biology

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