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Changes in hypothalamic staining for c-Fos following 2G exposure in ratsThe static gravitational field of the earth has been an important selective pressure that has shaped the evolution of biological organisms. This is illustrated by the evolution of tetrapods from a water environment where gravitational force was partially negated to a terrestrial environment where gravity is of greater consequence. Terrestrial invasion resulted in a series of new structural, physiological, and behavioral features. Therefore, it is not surprising that alterations in the gravitational field can cause widespread effects in many physiological systems and behaviors. Our previous studies have demonstrated that both exposure to hyperdynamic fields and the microgravity condition of space flight have significant effects on body temperature, heartrate, activity, feeding, drinking, and circadian rhythms. However, it has not been determined whether these physiological adaptations are associated with changes in neural activity within the hypothalamic nuclei that regulate these functions. This study examined the changes in body temperature, activity, body weight and food and water intake in rats caused by exposure to a hyperdynamic field. In addition, the immediate early gene activation marker, c-Fos, was used to examine potential protein synthesis changes in the hypothalamic nuclei that regulate these functions.
Document ID
20040089962
Acquisition Source
Ames Research Center
Document Type
Reprint (Version printed in journal)
Authors
Fuller, C. A.
(University of California Davis 95616-8519, United States)
Murakami, D. M.
Hoban-Higgins, T. M.
Tang, I. H.
Date Acquired
August 21, 2013
Publication Date
May 1, 1994
Publication Information
Publication: Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology
Volume: 1
Issue: 1
ISSN: 1077-9248
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: NAG2-840
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Regulatory Physiology
Non-NASA Center
NASA Program Space Physiology and Countermeasures
NASA Discipline Number 18-10

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