NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
Integrin-extracellular matrix interactions in connective tissue remodeling and osteoblast differentiationThe differentiaton of bone cells is a complex multistep process. Bone is somewhat unusual in that it is very actively and continually remodeled in the adult and that maintenance of its mass in the mature organism is exquisitely sensitive to mechanical as well as chemical signals. Bone is also unique because it consists of a very large amount of extracellular matrix (ECM) that is mineralized. The integrin family of ECM receptors has been shown to play an important role in tissue morphogenesis in several systems. Our studies on the regulation of matrix remodeling enzymes by integrins in rabbit synovial fibroblasts show that two b1 integrin fibronectin (FN) receptor complexes (alpha 5 beta 1 and alpha 4 beta 1) cooperate in detecting subtle changes in the composition of the ECM. As a result of signal transduction by these integrins, the levels of mRNA and protein for several members of the metalloproteinase family are regulated in these cells. We have also used antibody and RGD peptide perturbation studies to determine the significance of cell/ECM interactions to normal osteogenesis. We found that interactions between the cell binding domain of FN and integrins are required for both normal morphogenesis and gene expression in cultured osteoblasts that differentiate to form bone-like tissue in culture. These data lead us to propose that beta 1 integrins play an important role in osteoblast differentiation as well as in bone remodeling.
Document ID
20040090019
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Globus, R. K.
(University of California San Francisco United States)
Moursi, A.
Zimmerman, D.
Lull, J.
Damsky, C.
Date Acquired
August 21, 2013
Publication Date
October 1, 1995
Publication Information
Publication: ASGSB bulletin : publication of the American Society for Gravitational and Space Biology
Volume: 8
Issue: 2
ISSN: 0898-4697
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Number 26-10
Non-NASA Center
NASA Discipline Musculoskeletal
NASA Program Space Physiology and Countermeasures

Available Downloads

There are no available downloads for this record.
No Preview Available