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Oncogenic transformation through the cell cycle and the LET dependent inverse dose rate effectSynchronised populations of mouse C3H/10T-1/2 cells were obtained by a stringent mitotic dislodgment procedure. Mitotic cells rapidly attach and progress sequentially through the cell cycle. Irradiation (3 Gy of X rays) was carried out at intervals from 0 to 18 h after initiating cell cycle progression of the mitotic cells. Oncogenic transformation was enhanced 10-fold over cells irradiated soon after replating (G1 and S phases) for cells in a near 2 h period corresponding to cells in G2 phase but not in mitosis. The cell surviving fraction had a 2-1/2-fold variation with resistant peaks corresponding to the late G1 and late S phases. These findings provide experimental support for the hypothesis initiated by Rossi and Kellerer and developed by Brenner and Hall to explain the LET dependent inverse dose rate effect for oncogenic transformation.
Document ID
20040090265
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Geard, C. R.
(Columbia University New York 10032, United States)
Miller, R. C.
Brenner, D. J.
Hall, E. J.
Wachholz, B. W.
Date Acquired
August 21, 2013
Publication Date
January 1, 1994
Publication Information
Publication: Radiation protection dosimetry
Volume: 52
Issue: 4-Jan
ISSN: 0144-8420
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: CA-49672
CONTRACT_GRANT: CA-12536
CONTRACT_GRANT: DE-FG01-88ER60631
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Radiation Health
Non-NASA Center

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