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The use of the tyrosine phosphatase antagonist orthovanadate in the study of a cell proliferation inhibitorIncubation of murine fibroblasts with orthovanadate, a global tyrosine phosphatase inhibitor, was shown to confer a "pseudo-transformed" phenotype with regard to cell morphology and growth characteristics. This alteration was manifested by both an increasing refractile appearance of the cells, consistent with many transformed cell lines, as well as an increase in maximum cell density was attained. Despite the abrogation of cellular tyrosine phosphatase activity, orthovanadate-treated cells remained sensitive to the biological activity of a naturally occurring sialoglycopeptide (SGP) cell surface proliferation inhibitor. The results indicated that tyrosine phosphatase activity, inhibited by orthovanadate, was not involved in the signal transduction pathway of the SGP.
Document ID
20040090343
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
Authors
Enebo, D. J.
(Kansas State University Manhattan 66506, United States)
Hanek, G.
Fattaey, H. K.
Johnson, T. C.
Spooner, B. S.
Date Acquired
August 21, 2013
Publication Date
April 1, 1993
Publication Information
Publication: Transactions of the Kansas Academy of Science
Volume: 96
Issue: 2-Jan
ISSN: 0022-8443
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: NAGW-1197
CONTRACT_GRANT: NAGW-2328
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Number 93-10
Non-NASA Center
NASA Program NSCORT
NASA Discipline Cell Biology

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