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Bystander CD4+ T lymphocytes survive in HIV-infected human lymphoid tissueHIV infection is associated with depletion of CD4(+) T cells. The mechanisms of this phenomenon remain to be understood. In particular, it remains controversial whether and to what extent uninfected ("bystander") CD4(+) T cells die in HIV-infected individuals. We address this question using a system of human lymphoid tissue ex vivo. Tissue blocks were inoculated with HIV-1. After productive infection was established, they were treated with the reverse transcriptase inhibitor nevirapine to protect from infection those CD4(+) T cells that had not yet been infected. These CD4(+) T cells residing in HIV-infected tissue are by definition bystanders. Our results demonstrate that after nevirapine application the number of bystander CD4(+) T cells is conserved. Thus, in the context of HIV-infected human lymphoid tissue, productive HIV infection kills infected cells but is not sufficient to cause the death of a significant number of uninfected CD4(+) T cells.
Document ID
20040101281
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Grivel, Jean-Charles
(NASA Headquarters Washington, DC United States)
Biancotto, Angelique
Ito, Yoshinori
Lima, Rosangela G.
Margolis, Leonid B.
Date Acquired
August 21, 2013
Publication Date
March 1, 2003
Publication Information
Publication: AIDS research and human retroviruses
Volume: 19
Issue: 3
ISSN: 0889-2229
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other

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