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Record Details

Record 28 of 315
Bystander CD4+ T lymphocytes survive in HIV-infected human lymphoid tissue
External Online Source: doi:10.1089/088922203763315713
Author and Affiliation:
Grivel, Jean-Charles(NASA, Washington DC United States)
Biancotto, Angelique
Ito, Yoshinori
Lima, Rosangela G.
Margolis, Leonid B.
Abstract: HIV infection is associated with depletion of CD4(+) T cells. The mechanisms of this phenomenon remain to be understood. In particular, it remains controversial whether and to what extent uninfected ("bystander") CD4(+) T cells die in HIV-infected individuals. We address this question using a system of human lymphoid tissue ex vivo. Tissue blocks were inoculated with HIV-1. After productive infection was established, they were treated with the reverse transcriptase inhibitor nevirapine to protect from infection those CD4(+) T cells that had not yet been infected. These CD4(+) T cells residing in HIV-infected tissue are by definition bystanders. Our results demonstrate that after nevirapine application the number of bystander CD4(+) T cells is conserved. Thus, in the context of HIV-infected human lymphoid tissue, productive HIV infection kills infected cells but is not sufficient to cause the death of a significant number of uninfected CD4(+) T cells.
Publication Date: Mar 01, 2003
Document ID:
20040101281
(Acquired Sep 16, 2004)
Subject Category: LIFE SCIENCES (GENERAL)
Document Type: Journal Article
Publication Information: AIDS research and human retroviruses; p. 211-6; (ISSN 0889-2229); Volume 19; 3
Publisher Information: United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: APOPTOSIS; HUMAN IMMUNODEFICIENCY VIRUS; IMMUNOLOGY; LYMPHATIC SYSTEM; LYMPHOCYTES; TISSUES (BIOLOGY); CYTOLOGY; CYTOMETRY
Other Descriptors: APOPTOSIS; CD4-POSITIVE T-LYMPHOCYTES/IMMUNOLOGY/PHYSIOLOGY/VIROLOGY; HIV INFECTIONS/IMMUNOLOGY/PATHOLOGY; HIV-1/IMMUNOLOGY; LYMPHOID TISSUE/CYTOLOGY/IMMUNOLOGY/VIROLOGY; FLOW CYTOMETRY; HUMAN; IN VITRO; TONSIL/CYTOLOGY/VIROLOGY
Availability Source: Other Sources
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