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Predicting functional divergence in protein evolution by site-specific rate shiftsMost modern tools that analyze protein evolution allow individual sites to mutate at constant rates over the history of the protein family. However, Walter Fitch observed in the 1970s that, if a protein changes its function, the mutability of individual sites might also change. This observation is captured in the "non-homogeneous gamma model", which extracts functional information from gene families by examining the different rates at which individual sites evolve. This model has recently been coupled with structural and molecular biology to identify sites that are likely to be involved in changing function within the gene family. Applying this to multiple gene families highlights the widespread divergence of functional behavior among proteins to generate paralogs and orthologs.
Document ID
20040109905
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gaucher, Eric A.
(NASA Headquarters Washington, DC United States)
Gu, Xun
Miyamoto, Michael M.
Benner, Steven A.
Date Acquired
August 21, 2013
Publication Date
June 1, 2002
Publication Information
Publication: Trends in biochemical sciences
Volume: 27
Issue: 6
ISSN: 0968-0004
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: R01 GM 62118
Distribution Limits
Public
Copyright
Other
Keywords
Review
Review, Tutorial

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