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Record Details

Record 98 of 14804
Polymerization of beta-amino acids in aqueous solution
External Online Source: doi:10.1023/A:1006580918298
Author and Affiliation:
Liu, R.(The Salk Institute for Biological Studies, San Diego, CA 92186-5800, United States)
Orgel, L. E.
Bada, J. L. [Principal Investigator]
Abstract: We have compared carbonyl diimidazole (CDI) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC) as activating agents for the oligomerization of negatively-charged alpha- and beta-amino acids in homogeneous aqueous solution. alpha-Amino acids can be oligomerized efficiently using CDI, but not by EDAC. beta-Amino acids can be oligomerized efficiently using EDAC, but not by CDI. Aspartic acid, an alpha- and beta-dicarboxylic acid is oligomerized efficiently by both reagents. These results are explained in terms of the mechanisms of the reactions, and their relevance to prebiotic chemistry is discussed.
Publication Date: Feb 01, 1998
Document ID:
20040112188
(Acquired Oct 05, 2004)
Subject Category: EXOBIOLOGY
Document Type: Journal Article
Publication Information: Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life (ISSN 0169-6149); Volume 28; 1; 47-60
Publisher Information: Netherlands
Contract/Grant/Task Num: NAGW-2881
Financial Sponsor: NASA; Washington DC United States
Description: In English
Distribution Limits: Unclassified; Publicly available; Unlimited
Rights: Copyright
NASA Terms: AMINO ACIDS; AQUEOUS SOLUTIONS; BIOLOGICAL EVOLUTION; DEOXYRIBONUCLEIC ACID; IMIDAZOLES; IMINES; POLYMERIZATION; POLYPEPTIDES; EXOBIOLOGY; ION CONCENTRATION; LIQUID CHROMATOGRAPHY; POLYMERS; SOLUTIONS; TEMPERATURE; WATER
Other Descriptors: AMINO ACIDS/CHEMISTRY; CARBODIIMIDES/CHEMISTRY; EVOLUTION, MOLECULAR; IMIDAZOLES/CHEMISTRY; OLIGOPEPTIDES/CHEMICAL SYNTHESIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COMPARATIVE STUDY; HYDROGEN-ION CONCENTRATION; POLYMERS/CHEMISTRY; SOLUTIONS; SUPPORT, U.S. GOV'T, NON-P.H.S; TEMPERATURE; WATER; NASA DISCIPLINE EXOBIOLOGY; NON-NASA CENTER
Availability Source: Other Sources
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