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Polymerization of beta-amino acids in aqueous solutionWe have compared carbonyl diimidazole (CDI) and 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide (EDAC) as activating agents for the oligomerization of negatively-charged alpha- and beta-amino acids in homogeneous aqueous solution. alpha-Amino acids can be oligomerized efficiently using CDI, but not by EDAC. beta-Amino acids can be oligomerized efficiently using EDAC, but not by CDI. Aspartic acid, an alpha- and beta-dicarboxylic acid is oligomerized efficiently by both reagents. These results are explained in terms of the mechanisms of the reactions, and their relevance to prebiotic chemistry is discussed.
Document ID
20040112188
Acquisition Source
Headquarters
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Liu, R.
(The Salk Institute for Biological Studies San Diego, CA 92186-5800, United States)
Orgel, L. E.
Bada, J. L.
Date Acquired
August 21, 2013
Publication Date
February 1, 1998
Publication Information
Publication: Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life
Volume: 28
Issue: 1
ISSN: 0169-6149
Subject Category
Exobiology
Funding Number(s)
CONTRACT_GRANT: NAGW-2881
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Exobiology
Non-NASA Center

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