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Biomaterials and bone mechanotransductionBone is an extremely complex tissue that provides many essential functions in the body. Bone tissue engineering holds great promise in providing strategies that will result in complete regeneration of bone and restoration of its function. Currently, such strategies include the transplantation of highly porous scaffolds seeded with cells. Prior to transplantation the seeded cells are cultured in vitro in order for the cells to proliferate, differentiate and generate extracellular matrix. Factors that can affect cellular function include the cell-biomaterial interaction, as well as the biochemical and the mechanical environment. To optimize culture conditions, good understanding of these parameters is necessary. The new developments in bone biology, bone cell mechanotransduction, and cell-surface interactions are reviewed here to demonstrate that bone mechanotransduction is strongly influenced by the biomaterial properties.
Document ID
20040112311
Document Type
Reprint (Version printed in journal)
Authors
Sikavitsas, V. I. (Institute of Biosciences and Bioengineering, Rice University Houston, TX 77005-18192, United States)
Temenoff, J. S.
Mikos, A. G.
McIntire, L. V.
Date Acquired
August 21, 2013
Publication Date
October 1, 2001
Publication Information
Publication: Biomaterials
Volume: 22
Issue: 19
ISSN: 0142-9612
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: R29-AR42639
Distribution Limits
Public
Copyright
Other
Keywords
Review
NASA Discipline Cell Biology
Review, Academic
Non-NASA Center