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It takes a tissue to make a tumor: epigenetics, cancer and the microenvironmentHow do normal tissues limit the development of cancer? This review discusses the evidence that normal cells effectively restrict malignant behavior, and that such tissue forces must be subjugated to establish a tumor. The action of ionizing radiation will be specifically discussed regarding the disruption of the microenvironment that promotes the transition from preneoplastic to neoplastic growth. Unlike the highly unpredictable nature of genetic mutations, the response of normal cells to radiation damage follows an epigenetic program similar to wound healing and other damage responses. Our hypothesis is that the persistent disruption of the microenvironment in irradiated tissue compromises its ability to suppress carcinogenesis.
Document ID
20040112331
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Barcellos-Hoff, M. H.
(Lawrence Berkeley National Laboratory Berkeley, California 94720, United States)
Chatterjee, A.
Date Acquired
August 21, 2013
Publication Date
April 1, 2001
Publication Information
Publication: Journal of mammary gland biology and neoplasia
Volume: 6
Issue: 2
ISSN: 1083-3021
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
Review, Tutorial
Review
NASA Discipline Radiation Health

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