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Modeled microgravity inhibits apoptosis in peripheral blood lymphocytesMicrogravity interferes with numerous lymphocyte functions (expression of cell surface molecules, locomotion, polyclonal and antigen-specific activation, and the protein kinase C activity in signal transduction). The latter suggests that gravity may also affect programmed cell death (PCD) in lymphocyte populations. To test this hypothesis, we investigated spontaneous, activation- and radiation-induced PCD in peripheral blood mononuclear cells exposed to modeled microgravity (MMG) using a rotating cell culture system. The results showed significant inhibition of radiation- and activation-induced apoptosis in MMG and provide insights into the potential mechanisms of this phenomenon.
Document ID
Document Type
Reprint (Version printed in journal)
Risin, D.
(Wyle Laboratories-Life Sciences, Systems and Services Houston, Texas 77058, United States)
Pellis, N. R.
McIntire, L. V.
Date Acquired
August 21, 2013
Publication Date
February 1, 2001
Publication Information
Publication: In vitro cellular & developmental biology. Animal
Volume: 37
Issue: 2
ISSN: 1071-2690
Subject Category
Aerospace Medicine
Distribution Limits
NASA Discipline Cell Biology
Non-NASA Center

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