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Suppression of antigen-specific lymphocyte activation in modeled microgravityVarious parameters of immune suppression are observed in lymphocytes from astronauts during and after a space flight. It is difficult to ascribe this suppression to microgravity effects on immune cells in crew specimens, due to the complex physiological response to space flight and the resultant effect on in vitro immune performance. Use of isolated immune cells in true and modeled microgravity in immune performance tests, suggests a direct effect of microgravity on in vitro cellular function. Specifically, polyclonal activation of T-cells is severely suppressed in true and modeled microgravity. These recent findings suggest a potential suppression of oligoclonal antigen-specific lymphocyte activation in microgravity. We utilized rotating wall vessel (RWV) bioreactors as an analog of microgravity for cell cultures to analyze three models of antigen-specific activation. A mixed-lymphocyte reaction, as a model for a primary immune response, a tetanus toxoid response and a Borrelia burgdorferi response, as models of a secondary immune response, were all suppressed in the RWV bioreactor. Our findings confirm that the suppression of activation observed with polyclonal models also encompasses oligoclonal antigen-specific activation.
Document ID
20040112465
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Cooper, D.
(La Jolla Institute for Allergy and Immunology San Diego, California 92121, United States)
Pride, M. W.
Brown, E. L.
Risin, D.
Pellis, N. R.
McIntire, L. V.
Date Acquired
August 21, 2013
Publication Date
February 1, 2001
Publication Information
Publication: In vitro cellular & developmental biology. Animal
Volume: 37
Issue: 2
ISSN: 1071-2690
Subject Category
Aerospace Medicine
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Cell Biology
Non-NASA Center

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