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Leiomodins: larger members of the tropomodulin (Tmod) gene familyThe 64-kDa autoantigen D1 or 1D, first identified as a potential autoantigen in Graves' disease, is similar to the tropomodulin (Tmod) family of actin filament pointed end-capping proteins. A novel gene with significant similarity to the 64-kDa human autoantigen D1 has been cloned from both humans and mice, and the genomic sequences of both genes have been identified. These genes form a subfamily closely related to the Tmods and are here named the Leiomodins (Lmods). Both Lmod genes display a conserved intron-exon structure, as do three Tmod genes, but the intron-exon structure of the Lmods and the Tmods is divergent. mRNA expression analysis indicates that the gene formerly known as the 64-kDa autoantigen D1 is most highly expressed in a variety of human tissues that contain smooth muscle, earning it the name smooth muscle Leiomodin (SM-Lmod; HGMW-approved symbol LMOD1). Transcripts encoding the novel Lmod gene are present exclusively in fetal and adult heart and adult skeletal muscle, and it is here named cardiac Leiomodin (C-Lmod; HGMW-approved symbol LMOD2). Human C-Lmod is located near the hypertrophic cardiomyopathy locus CMH6 on human chromosome 7q3, potentially implicating it in this disease. Our data demonstrate that the Lmods are evolutionarily related and display tissue-specific patterns of expression distinct from, but overlapping with, the expression of Tmod isoforms. Copyright 2001 Academic Press.
Document ID
20040112474
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Conley, C. A. (NASA Ames Research Center Moffett Field CA United States)
Fritz-Six, K. L.
Almenar-Queralt, A.
Fowler, V. M.
Date Acquired
August 21, 2013
Publication Date
April 15, 2001
Publication Information
Publication: Genomics
Volume: 73
Issue: 2
ISSN: 0888-7543
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: GM-34225
Distribution Limits
Public
Copyright
Other