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Novel effects of nitric oxideNitric oxide (NO), a simple free radical gas, elicits a surprisingly wide range of physiological and pathophysiological effects. NO interacts with soluble guanylate cyclase to evoke many of these effects. However, NO can also interact with molecular oxygen and superoxide radicals to produce reactive nitrogen species that can modify a number of macromolecules including proteins, lipids, and nucleic acids. NO can also interact directly with transition metals. Here, we have reviewed the non--3',5'-cyclic-guanosine-monophosphate-mediated effects of NO including modifications of proteins, lipids, and nucleic acids.
Document ID
20040112511
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Davis, K. L.
(University of Texas Houston Health Science Center Houston, Texas 77030, United States)
Martin, E.
Turko, I. V.
Murad, F.
Date Acquired
August 21, 2013
Publication Date
January 1, 2001
Publication Information
Publication: Annual review of pharmacology and toxicology
Volume: 41
ISSN: 0362-1642
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL10046-02
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
Review
Review, Academic
NASA Discipline Cardiopulmonary

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