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Differential global gene expression in red and white skeletal muscleThe differences in gene expression among the fiber types of skeletal muscle have long fascinated scientists, but for the most part, previous experiments have only reported differences of one or two genes at a time. The evolving technology of global mRNA expression analysis was employed to determine the potential differential expression of approximately 3,000 mRNAs between the white quad (white muscle) and the red soleus muscle (mixed red muscle) of female ICR mice (30-35 g). Microarray analysis identified 49 mRNA sequences that were differentially expressed between white and mixed red skeletal muscle, including newly identified differential expressions between muscle types. For example, the current findings increase the number of known, differentially expressed mRNAs for transcription factors/coregulators by nine and signaling proteins by three. The expanding knowledge of the diversity of mRNA expression between white and mixed red muscle suggests that there could be quite a complex regulation of phenotype between muscles of different fiber types.
Document ID
20040112528
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Campbell, W. G.
(University of Texas Medical School Houston, TX 77030, United States)
Gordon, S. E.
Carlson, C. J.
Pattison, J. S.
Hamilton, M. T.
Booth, F. W.
Date Acquired
August 21, 2013
Publication Date
April 1, 2001
Publication Information
Publication: American journal of physiology. Cell physiology
Volume: 280
Issue: 4
ISSN: 0363-6143
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: HL-57367
CONTRACT_GRANT: AR-19393
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Musculoskeletal

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