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Vestibular efferent neurons project to the flocculusA bilateral projection from the vestibular efferent neurons, located dorsal to the genu of the facial nerve, to the cerebellar flocculus and ventral paraflocculus was demonstrated. Efferent neurons were double-labeled by the unilateral injections of separate retrograde tracers into the labyrinth and into the floccular and ventral parafloccular lobules. Efferent neurons were found with double retrograde tracer labeling both ipsilateral and contralateral to the sites of injection. No double labeling was found when using a fluorescent tracer with non-fluorescent tracers such as horseradish peroxidase (HRP) or biotinylated dextran amine (BDA), but large percentages of efferent neurons were found to be double labeled when using two fluorescent substances including: fluorogold, microruby dextran amine, or rhodamine labeled latex beads. These data suggest a potential role for vestibular efferent neurons in modulating the dynamics of the vestibulo-ocular reflex (VOR) during normal and adaptive conditions.
Document ID
20040112594
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Shinder, M. E.
(University of Texas Medical Branch, Department of Otolaryngology 7.102 MRB, Galveston, TX 77555-1063, United States)
Purcell, I. M.
Kaufman, G. D.
Perachio, A. A.
Date Acquired
August 21, 2013
Publication Date
January 19, 2001
Publication Information
Publication: Brain research
Volume: 889
Issue: 2-Jan
ISSN: 0006-8993
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: DC-00385
CONTRACT_GRANT: DC-00111
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Neuroscience

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