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Know thy neighbor: stromal cells can contribute oncogenic signalsAlthough the stroma within carcinogenic lesions is known to be supportive and responsive to tumors, new data increasingly show that the stroma also has a more active, oncogenic role in tumorigenesis. Stromal cells and their products can transform adjacent tissues in the absence of pre-existing tumor cells by inciting phenotypic and genomic changes in the epithelial cells. The oncogenic action of distinctive stromal components has been demonstrated through a variety of approaches, which provide clues about the cellular pathways involved.
Document ID
20040112598
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Tlsty, T. D.
(University of California at San Francisco San Francisco, California 94143-0506, United States)
Hein, P. W.
Date Acquired
August 21, 2013
Publication Date
February 1, 2001
Publication Information
Publication: Current opinion in genetics & development
Volume: 11
Issue: 1
ISSN: 0959-437X
Subject Category
Life Sciences (General)
Distribution Limits
Public
Copyright
Other
Keywords
Review
Review, Tutorial
Non-NASA Center
NASA Discipline Radiation Health

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