NASA Logo

NTRS

NTRS - NASA Technical Reports Server

Back to Results
ANG II is required for optimal overload-induced skeletal muscle hypertrophyANG II mediates the hypertrophic response of overloaded cardiac muscle, likely via the ANG II type 1 (AT(1)) receptor. To examine the potential role of ANG II in overload-induced skeletal muscle hypertrophy, plantaris and/or soleus muscle overload was produced in female Sprague-Dawley rats (225-250 g) by the bilateral surgical ablation of either the synergistic gastrocnemius muscle (experiment 1) or both the gastrocnemius and plantaris muscles (experiment 2). In experiment 1 (n = 10/group), inhibiting endogenous ANG II production by oral administration of an angiotensin-converting enzyme (ACE) inhibitor during a 28-day overloading protocol attenuated plantaris and soleus muscle hypertrophy by 57 and 96%, respectively (as measured by total muscle protein content). ACE inhibition had no effect on nonoverloaded (sham-operated) muscles. With the use of new animals (experiment 2; n = 8/group), locally perfusing overloaded soleus muscles with exogenous ANG II (via osmotic pump) rescued the lost hypertrophic response in ACE-inhibited animals by 71%. Furthermore, orally administering an AT(1) receptor antagonist instead of an ACE inhibitor produced a 48% attenuation of overload-induced hypertrophy that could not be rescued by ANG II perfusion. Thus ANG II may be necessary for optimal overload-induced skeletal muscle hypertrophy, acting at least in part via an AT(1) receptor-dependent pathway.
Document ID
20040112658
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Gordon, S. E.
(University of Texas--Houston Health Science Center Houston, Texas 77030, United States)
Davis, B. S.
Carlson, C. J.
Booth, F. W.
Date Acquired
August 21, 2013
Publication Date
January 1, 2001
Publication Information
Publication: American journal of physiology. Endocrinology and metabolism
Volume: 280
Issue: 1
ISSN: 0193-1849
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: AR-19393
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Non-NASA Center

Available Downloads

There are no available downloads for this record.
No Preview Available