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The timing of the human circadian clock is accurately represented by the core body temperature rhythm following phase shifts to a three-cycle light stimulus near the critical zoneA double-stimulus experiment was conducted to evaluate the phase of the underlying circadian clock following light-induced phase shifts of the human circadian system. Circadian phase was assayed by constant routine from the rhythm in core body temperature before and after a three-cycle bright-light stimulus applied near the estimated minimum of the core body temperature rhythm. An identical, consecutive three-cycle light stimulus was then applied, and phase was reassessed. Phase shifts to these consecutive stimuli were no different from those obtained in a previous study following light stimuli applied under steady-state conditions over a range of circadian phases similar to those at which the consecutive stimuli were applied. These data suggest that circadian phase shifts of the core body temperature rhythm in response to a three-cycle stimulus occur within 24 h following the end of the 3-day light stimulus and that this poststimulus temperature rhythm accurately reflects the timing of the underlying circadian clock.
Document ID
20040112666
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
Authors
Jewett, M. E.
(Brigham and Women's Hospital, Harvard Medical School Boston, MA 02115, United States)
Duffy, J. F.
Czeisler, C. A.
Date Acquired
August 21, 2013
Publication Date
December 1, 2000
Publication Information
Publication: Journal of biological rhythms
Volume: 15
Issue: 6
ISSN: 0748-7304
Subject Category
Life Sciences (General)
Funding Number(s)
CONTRACT_GRANT: F33-HL09588
CONTRACT_GRANT: MO1-RR02635
CONTRACT_GRANT: RO1-MH45130
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Regulatory Physiology

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