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Effect of hindlimb suspension and clenbuterol treatment on polyamine levels in skeletal musclePolyamines are unbiquitous, naturally occurring small aliphatic, polycationic, endogenous compounds. They are involved in many cellular processes and may serve as secondary or tertiary messengers to hormonal regulation. The relationship of polyamines and skeletal muscle mass of adductor longus, extensor digitorum longus, and gastrocnemius under unloading (hindlimb suspension) conditions was investigated. Unloading significantly affected skeletal muscle polyamine levels in a fiber-type-specific fashion. Under loading conditions, clenbuterol treatment increased all polyamine levels, whereas under unloading conditions, only the spermidine levels were consistently increased. Unloading attenuated the anabolic effects of clenbuterol in predominately slow-twitch muscles (adductor longus), but had little impact on clenbuterol's action as a countermeasure in fast- twitch muscles such as the extensor digitorum longus. Spermidine appeared to be the primary polyamine involved in skeletal muscle atrophy/hypertrophy. Copyright 2002 S. Karger AG, Basel.
Document ID
20040112968
Acquisition Source
Legacy CDMS
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Abukhalaf, Imad K.
(Morehouse School of Medicine Atlanta, GA 30310-1495, United States)
von Deutsch, Daniel A.
Wineski, Lawrence E.
Silvestrov, Natalia A.
Abera, Saare A.
Sahlu, Sinafikish W.
Potter, David E.
Thierry-Palmer, M.
Date Acquired
August 21, 2013
Publication Date
July 1, 2002
Publication Information
Publication: Pharmacology
Volume: 65
Issue: 3
ISSN: 0031-7012
Subject Category
Aerospace Medicine
Funding Number(s)
CONTRACT_GRANT: P20RR11104-07
Distribution Limits
Public
Copyright
Other
Keywords
NASA Discipline Musculoskeletal
Non-NASA Center

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