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Conservation of Pax gene expression in ectodermal placodes of the lampreyEctodermal placodes contribute to the cranial ganglia and sense organs of the head and, together with neural crest cells, represent defining features of the vertebrate embryo. The identity of different placodes appears to be specified in part by the expression of different Pax genes, with Pax-3/7 class genes being expressed in the trigeminal placode of mice, chick, frogs and fish, and Pax-2/5/8 class genes expressed in the otic placode. Here, we present the cloning and expression pattern of lamprey Pax-7 and Pax-2, which mark the trigeminal and otic placodes, respectively, as well as other structures characteristic of vertebrate Pax genes. These results suggest conservation of Pax genes and placodal structures in basal and derived vertebrates.
Document ID
Document Type
Reprint (Version printed in journal)
McCauley, David W.
(California Institute of Technology Pasadena, CA 91125, United States)
Bronner-Fraser, Marianne
Date Acquired
August 21, 2013
Publication Date
April 3, 2002
Publication Information
Publication: Gene
Volume: 287
Issue: 1-2
ISSN: 0378-1119
Subject Category
Life Sciences (General)
Distribution Limits
NASA Discipline Evolutionary Biology
Non-NASA Center

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