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N-Acetyl-D- and L-esters of 5'-AMP hydrolyze at different ratesStudies of the properties of aminoacyl derivatives of 5'-AMP are aimed at understanding the origin of the process of protein synthesis. Aminoacyl (2',3') esters of 5'-AMP can serve as models of the 3'-terminus of aminoacyl tRNA. We report here on the relative rates of hydrolysis of Ac-D- and L-Phe AMP esters as a function of pH. At all pHs above 3, the rate constant of hydrolysis of the Ac-L-Phe ester is 1.7 to 2.1 times that of Ac-D-Phe ester. The D-isomer seems partially protected from hydrolysis by a stronger association with the adenine ring of the 5'-AMP.
Document ID
20040121336
Document Type
Reprint (Version printed in journal)
External Source(s)
Authors
Wickramasinghe, N. S. (University of Alabama at Birmingham United States)
Lacey, J. C. Jr
Lacey JC, J. r.
Date Acquired
August 22, 2013
Publication Date
January 1, 1993
Publication Information
Publication: Chirality
Volume: 5
ISSN: 0899-0042
Subject Category
Exobiology
Distribution Limits
Public
Copyright
Other
Keywords
Non-NASA Center
NASA Discipline Exobiology