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Effect of Oxygen-containing Functional Groups on Protein Stability in Ionic Liquid SolutionsThe ability of functionalized ionic liquids (ILs) to provide an environment of increased stability for biomolecules has been studied. Serum albumin is an inexpensive, widely available protein that contributes to the overall colloid osmotic blood pressure within the vascular system. Albumin is used in the present study as a marker of biomolecular stability in the presence of various ILs in a range of concentrations. The incorporation of hydroxyl functionality into the methylimidazolium-based cation leads to increased protein stability detected by fluorescence spectroscopy and circular dichroic (CD) spectrometry.
Document ID
20040129636
Acquisition Source
Marshall Space Flight Center
Document Type
Book
Authors
Turner, Megan B.
(Alabama Univ. Tuscaloosa, AL, United States)
Holbrey, John D.
(Alabama Univ. Tuscaloosa, AL, United States)
Spear, Scott K.
(Alabama Univ. Tuscaloosa, AL, United States)
Pusey, Marc L.
(NASA Marshall Space Flight Center Huntsville, AL, United States)
Rogers, Robin D.
(Alabama Univ. Tuscaloosa, AL, United States)
Date Acquired
August 22, 2013
Publication Date
January 1, 2004
Publication Information
Publication: Adv. Protein Chem.
Volume: 45
Subject Category
Inorganic, Organic And Physical Chemistry
Distribution Limits
Public
Copyright
Other

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